abstract：:Single-prolonged stress (SPS) is an established animal model for post-traumatic stress disorder (PTSD). The calcium (Ca2+)-calmodulin (CaM)-CaM kinase (K)IIalpha signal passage plays an important role in the plasticity of central nervous, learning and memory, mind and behavior and other types of cognitive activities. ...

journal_title：International journal of molecular medicine

authors： Xiao B,Han F,Shi YX

更新日期：2009-12-01 00:00:00

abstract：:A dietary deprivation in long-chain polyunsaturated omega3 fatty acids initiated in 7-week old normal rats provokes within 3 to 7 months the appearance of several features of the metabolic syndrome. Likewise, within 2 to 4-5 weeks exposure to a flaxseed oil-enriched diet, these anomalies are rapidly corrected. The pre...

journal_title：International journal of molecular medicine

authors： Hacquebard M,Portois L,Malaisse WJ,Carpentier YA

更新日期：2009-12-01 00:00:00

abstract：:White blood cell (WBC) count is considered a prognostic risk factor in acute myeloid leukemia. As density of leukemic cells increases, the cytotoxic activity of certain anticancer drugs, such as vincristine and doxorubicin, progressively decreases. In this study, we investigated the cell density-dependent induction of...

journal_title：International journal of molecular medicine

authors： Navrátilová J,Jungová P,Vanhara P,Preisler J,Kanicky V,Smarda J

更新日期：2009-11-01 00:00:00

abstract：:The present study reports the identification of human sex hormone binding globulin (SHBG)-interacting proteins in the brain using a phage display-based screening technology. Phage display is a system in which a foreign protein is displayed on the surface of a bacteriophage as a fusion protein with one of the coat prot...

journal_title：International journal of molecular medicine

authors： Gnanasekar M,Suleman FG,Ramaswamy K,Caldwell JD

更新日期：2009-10-01 00:00:00

abstract：:We isolated two phytochemical lignans, schisandrin and schisandrin C, from Schizandra chinensis Baill and investigated their anti-cancer effects in human leukemia U937 cells. Schisandrin C inhibited cell growth in a dose-dependent manner, which was associated with the induction of G1 arrest of the cell cycle and apopt...

journal_title：International journal of molecular medicine

authors： Park C,Choi YW,Hyun SK,Kwon HJ,Hwang HJ,Kim GY,Choi BT,Kim BW,Choi IW,Moon SK,Kim WJ,Choi YH

更新日期：2009-10-01 00:00:00

abstract：:Synovial membrane consists of fibroblasts and macrophages forming the synovial lining supported by vascularized subsynovium. Each of these components may specifically react to a particular stimulus. Thus, reactions of isolated synovial cells may not correspond to that of intact tissue. We characterized the production ...

journal_title：International journal of molecular medicine

authors： Hyc A,Osiecka-Iwan A,Niderla-Bielinska J,Jankowska-Steifer E,Moskalewski S

更新日期：2009-10-01 00:00:00

abstract：:The clinical diagnosis of cutaneous melanoma always calls for histological confirmation. In addition to the recognition of the classic aspects of the neoplasm, immunohistochemistry is determinant, in particular in the assessment of the size of the replicative compartment. Generally, the proliferation rate is indicativ...

journal_title：International journal of molecular medicine

authors： Quatresooz P,Pierard GE,Pierard-Franchimont C,Mosan Study Group of Pigmented Tumors.

更新日期：2009-09-01 00:00:00

abstract：:Parathyroid hormone (PTH) is the primary regulator of serum calcium homeostasis and bone metabolism. PTH acts primarily by binding to its receptor, PTH1R, in the bone and kidney. In addition to PTH, PTH1R also recognizes PTH-related peptide (PTHrP), a paracrine/autocrine factor originally described as the hormone resp...

journal_title：International journal of molecular medicine

authors： Müller M,Gagiannis S,Nawroth PP,Brune M,Schilling T

更新日期：2009-09-01 00:00:00

abstract：:The mechanistic significance of oxidative stress to fibrogenesis in the methionine and choline-deficient (MCD) diet-induced model of steatohepatitis was evaluated by antioxidant intervention, using either vitamin E or L-2-oxothiazolidine-4-carboxylate (OTC), a cysteine precursor that promotes glutathione synthesis. Si...

journal_title：International journal of molecular medicine

authors： Phung N,Pera N,Farrell G,Leclercq I,Hou JY,George J

更新日期：2009-08-01 00:00:00

abstract：:Rats exposed from 7 weeks after birth and for the ensuing 3 to 7 months to a diet depleted in long-chain polyunsaturated omega3 fatty acids were recently proposed as a new animal model for the metabolic syndrome. The present study aimed mainly at investigating whether, in this new model, the perturbation of the fatty ...

journal_title：International journal of molecular medicine

authors： Portois L,Hacquebard M,Malaisse WJ,Carpentier YA

更新日期：2009-08-01 00:00:00

abstract：:Insulinoma-associated protein 2 (IA-2) is the major autoantigen that contributes to the pathogenesis of type 1 diabetes (T1D). IA-2-deficient (IA-2-/-) mice showed impaired insulin secretion after intraperitoneal injection of glucose as well as elevated glucose level in a glucose tolerance test. Despite the fact that ...

journal_title：International journal of molecular medicine

authors： Nakajima K,Wu G,Takeyama N,Sakudo A,Sugiura K,Yukawa M,Onodera T

更新日期：2009-07-01 00:00:00

abstract：:Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease....

journal_title：International journal of molecular medicine

authors： Yim SY,Chae KR,Shim SB,Hong JT,Park JY,Lee CY,Son HJ,Sheen YY,Hwang DY

更新日期：2009-07-01 00:00:00

abstract：:Adult mesenchymal progenitor cells (MPCs) are adherent stromal cells of non-haematopoietic origin derived from bone marrow and other tissues. Upon limited in vitro expansion, they retain their self-renewal capacity as well as their potential to differentiate into tissues of mesenchymal lineage, such as bone, cartilage...

journal_title：International journal of molecular medicine

authors： Grässel S,Ahmed N,Göttl C,Grifka J

更新日期：2009-06-01 00:00:00

abstract：:High mobility group box-1 protein (HMGB1), primarily from the nucleus, is released into the extracellular milieu either passively from necrotic cells or actively through secretion by monocytes/macrophages. Extracellular HMGB1 acts as a potent inflammatory agent by promoting the release of cytokines such as tumor necro...

journal_title：International journal of molecular medicine

authors： Kawahara K,Hashiguchi T,Masuda K,Saniabadi AR,Kikuchi K,Tancharoen S,Ito T,Miura N,Morimoto Y,Biswas KK,Nawa Y,Meng X,Oyama Y,Takenouchi K,Shrestha B,Sameshima H,Shimizu T,Adachi T,Adachi M,Maruyama I

更新日期：2009-05-01 00:00:00

abstract：:Oxidative burst provides the mechanism for specialized phagocytes, such as granulocytes or monocytes, to kill invading microorganisms through generation of superoxide anions. However, the oxidants generated during the burst damage DNA of the phagocytes and neighboring cells. Human blood leukocytes treated with phorbol...

journal_title：International journal of molecular medicine

authors： Halicka HD,Mitlitski V,Heeter J,Balazs EA,Darzynkiewicz Z

更新日期：2009-05-01 00:00:00

abstract：:Microtraumata often lead to articular cartilage lesions. Due to the bradytrophic character of hyaline cartilage, these lesions are hardly repaired by the organism. Autologous chondrocyte implantation (ACI) was established for restoring isolated structural cartilage defects in knee joints. However, results are not alwa...

journal_title：International journal of molecular medicine

authors： Schubert T,Anders S,Neumann E,Schölmerich J,Hofstädter F,Grifka J,Müller-Ladner U,Libera J,Schedel J

更新日期：2009-04-01 00:00:00

abstract：:Although diabetes mellitus has been recognized as a risk factor for chronic kidney disease (CKD), genetic factors for predisposition to CKD in individuals with diabetes mellitus remain elucidated. The purpose of the present study was to identify genetic variants that confer susceptibility to CKD among individuals with...

journal_title：International journal of molecular medicine

authors： Yoshida T,Kato K,Yokoi K,Watanabe S,Metoki N,Yoshida H,Satoh K,Aoyagi Y,Nishigaki Y,Suzuki T,Nozawa Y,Yamada Y

更新日期：2009-04-01 00:00:00

abstract：:Atopic dermatitis (AD) shows an increased susceptibility to Staphylococcus aureus infection partly due to decreased expression of human beta-defensin-2 (HBD-2). Interestingly, it was reported that the nasal carrier S. aureus down-regulates the expression of HBD-2 and -3, thereby the carrier strains of S. aureus retain...

journal_title：International journal of molecular medicine

authors： Cho JW,Cho SY,Lee KS

更新日期：2009-03-01 00:00:00

abstract：:Bisphosphonates consist of a family of pyrophosphate analogues that are currently being used to treat metastatic bone diseases as well as systemic bone diseases such as osteoporosis. There is accumulating evidence suggesting that patients treated with these bisphosphonates can develop, particularly with invasive denta...

journal_title：International journal of molecular medicine

authors： Rao MV,Berk J,Almojaly SA,Goodloe Iii S,Margarone Iii J,Sullivan M,Dziak R

更新日期：2009-03-01 00:00:00

abstract：:We investigated the expression and function of laminin and type IV collagen (COL-4) in the human endometrial epithelium throughout the menstrual cycle. Their expression was demonstrated by immunohistochemistry, while cytological analysis of the human endometrial epithelial cell line HHUA cultured on laminin- or COL-4-...

journal_title：International journal of molecular medicine

authors： Tanaka T,Wang C,Umesaki N

更新日期：2009-02-01 00:00:00

abstract：:The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular carti...

journal_title：International journal of molecular medicine

authors： Albrecht C,Schlegel W,Eckl P,Jagersberger T,Sadeghi K,Berger A,Vécsei V,Marlovits S

更新日期：2009-02-01 00:00:00

abstract：:The enhancement and promotion of health is necessary to maintain the quality of life (QOL) of the aged population in developed nations such as Japan where the number of elderly has been increasing rapidly. For this purpose, low-resistance training using exercise machines ('Power Rehabilitation') has been established a...

journal_title：International journal of molecular medicine

authors： Murakami S,Otsuki T,Maeda M,Miura Y,Morii S,Kiyokane K,Hayakawa S,Maeda A,Imakawa T,Harada S,Handa T,Nishimura Y,Murakami S,Kumagai N,Hayashi H,Chen Y,Suemori S,Fukushima Y,Nishida S,Fukushima K

更新日期：2009-01-01 00:00:00

abstract：:We investigated the effects of a nutrient mixture (NM) consisting of ascorbic acid, quercetin, naringenin, hesperetin, tea catechins, lysine, proline, arginine and N-acetylcysteine on experimental in vivo and in vitro inflammation triggered by bacterial lipopolysaccharide (LPS). BALB/c mice (n=36) were administered NM...

journal_title：International journal of molecular medicine

authors： Ivanov V,Cha J,Ivanova S,Kalinovsky T,Roomi MW,Rath M,Niedzwiecki A

更新日期：2008-12-01 00:00:00

abstract：:Atherosclerosis is now considered a chronic inflammatory disease, and glucosamine has the potential to exhibit an anti-inflammatory action. Thus, we investigated the effect of glucosamine on tumor necrosis factor alpha (TNF-alpha)-induced endothelial cell activation. Human umbilical vein endothelial cells (HUVECs) wer...

journal_title：International journal of molecular medicine

authors： Ju Y,Hua J,Sakamoto K,Ogawa H,Nagaoka I

更新日期：2008-12-01 00:00:00

abstract：:This study examined the mechanism for the anti-cancer effects of histone deacetylase (HDAC) inhibitor trichostatin A (TsA) in H-ras-transformed human breast epithelial (MCF10A-ras) cells. The effects of TsA on anti-cancer effects of MCF10A-ras cells were determined by measuring the level of cell cycle regulator expres...

journal_title：International journal of molecular medicine

authors： Park H,Lee YJ,Kim TH,Lee J,Yoon S,Choi WS,Myung CS,Kim HS

更新日期：2008-11-01 00:00:00

abstract：:Schiff bases have been intensively investigated due to their antibacterial and antitumor properties. Copper is a cofactor essential for the tumor angiogenesis processes, whereas other transition metals are not. Consistently, high serum or tissue levels of copper were found in many types of human cancer including breas...

journal_title：International journal of molecular medicine

authors： Zhang X,Bi C,Fan Y,Cui Q,Chen D,Xiao Y,Dou QP

更新日期：2008-11-01 00:00:00

abstract：:We have recently established a clonal mesenchymal stem cell line (rBM25/S3) from adult rat bone marrow. The cells have practically unlimited proliferation capacity (over 300 PDL), maintaining multipotency for differentiation. In the present study, we examined the potential for rBM25/S3 cells to differentiate into insu...

journal_title：International journal of molecular medicine

authors： Masaka T,Miyazaki M,Du G,Hardjo M,Sakaguchi M,Takaishi M,Kataoka K,Yamamoto K,Huh NH

更新日期：2008-10-01 00:00:00

abstract：:Fatty liver is one of the local morphological manifestations of metabolic syndrome and is frequently associated with insulin resistance. Insulin resistance is also common in patients with chronic hepatitis C. Hyperinsulinemia is an independent risk factor for hypertension and cardiovascular mortality. The aim of this ...

journal_title：International journal of molecular medicine

authors： Enjoji M,Kotoh K,Kato M,Higuchi N,Kohjima M,Nakashima M,Nakamuta M

更新日期：2008-10-01 00:00:00

abstract：:Glucosamine, a naturally occurring amino monosaccharide, is widely used to treat osteoarthritis in humans. Furthermore, glucosamine exhibits an anti-inflammatory action by inhibiting the activation of neutrophils, chondrocytes and synoviocytes. Recently, we revealed that glucosamine suppresses cytokine-induced activat...

journal_title：International journal of molecular medicine

authors： Yomogida S,Kojima Y,Tsutsumi-Ishii Y,Hua J,Sakamoto K,Nagaoka I

更新日期：2008-09-01 00:00:00

abstract：:Currently, several therapeutic approaches including surgery, chemotherapy, and radiation therapy are available for the treatment of endometrial cancer. However, endometrial cancer cells may survive, resulting in relapse of the disease, and ultimately causing demise of the patient. Hepsin is a cell surface-expressed ch...

journal_title：International journal of molecular medicine

authors： Nakamura K,Takamoto N,Abarzua F,Hongo A,Kodama J,Nasu Y,Kumon H,Hiramatsu Y

更新日期：2008-09-01 00:00:00

abstract：:Mutations in mitochondrial DNA (mtDNA) are a major cause of hearing loss. In this study, we performed a systematic mutational screening of the 12S rRNA, tRNA Ser(UCN), tRNA Lys and tRNA Leu(UUR) genes in 227 unrelated patients with nonsyndromic hearing impairment for the first time in a Korean population. We found two...

journal_title：International journal of molecular medicine

authors： Bae JW,Lee KY,Choi SY,Lee SH,Park HJ,Kim UK

更新日期：2008-08-01 00:00:00

abstract：:Soy sauce (Shoyu) is a traditional Japanese fermented seasoning and is available worldwide. We investigated the effect of Shoyu polysaccharides (SPS) prepared from soy sauce on the intestinal immune system of mice. SPS enhanced the production of immunoglobulin A (IgA) from Peyer's patch cells in vitro, and its oral ad...

journal_title：International journal of molecular medicine

authors： Matsushita H,Kobayashi M,Tsukiyama R,Fujimoto M,Suzuki M,Tsuji K,Yamamoto K

更新日期：2008-08-01 00:00:00

abstract：:Vitiligo is an acquired and progressive disorder manifested by the selective destruction of melanocytes in the skin. An extremely high level of hydrogen peroxide (H2O2) in plasma as well as in lesional skin has been reported in vitiligo patients. High H2O2 level has been suggested to be responsible for the disappearan...

journal_title：International journal of molecular medicine

authors： Song X,Xu A,Pan W,Wallin B,Kivlin R,Lu S,Cao C,Bi Z,Wan Y

更新日期：2008-07-01 00:00:00

abstract：:Cadmium (Cd) is an industrial pollutant and carcinogenic metal. Most in vitro Cd toxicity studies have been carried out in various cell lines cultured in 10% fetal bovine serum (FBS) containing medium. In this report, we compared the toxic effect of Cd (0-300 microM) on cell growth, total RNA, total proteins, and anti...

journal_title：International journal of molecular medicine

authors： Latinwo LM,Badisa VL,Odewumi CO,Ikediobi CO,Badisa RB,Brooks-Walter A,Lambert AT,Nwoga J

更新日期：2008-07-01 00:00:00

abstract：:Neuromedin-U (NMU) is a brain-gut peptide, which has been previously found to stimulate hypothalamic-pituitary-adrenal axis in the rat. Enucleation-induced adrenal regeneration in rats with contralateral adrenalectomy is a well-established model of adrenal growth, that not only depends on the compensatory ACTH hyperse...

journal_title：International journal of molecular medicine

authors： Trejter M,Neri G,Rucinski M,Majchrzak M,Nussdorfer GG,Malendowicz LK

更新日期：2008-06-01 00:00:00

abstract：:Epidemiological and experimental carcinogenesis studies provide evidence that certain components of garlic have anti-cancer activity. Although the biotransformed garlic derivative S-allylmercapto-L-cysteine (SAMC) has been reported to show an inhibitory effect on tumorigenesis, the mechanisms are poorly understood. Th...

journal_title：International journal of molecular medicine

authors： Lee Y

更新日期：2008-06-01 00:00:00

abstract：:The thermo-enhancement effects of the sesquiterpene lactone parthenolide (PTL), which targets the transcription factor nuclear factor-kappaB (NF-kappaB), and hyperthermia at 40, 42 and 44 degrees C on the human lung adenocarcinoma A549 cell line were investigated in vitro. Thermotherapy using a combined treatment with...

journal_title：International journal of molecular medicine

authors： Hayashi S,Hatashita M,Hayashi A,Matsumoto H,Shioura H,Kitai R

更新日期：2008-05-01 00:00:00

abstract：:Chronic rhinosinusitis (CRS) is one of the most common chronic diseases. The etiology and classification of CRS, with and without nasal polyps, remain unclear. Eosinophils and their products are important in the pathophysiology of allergic diseases and in host immunity to certain organisms. Interleukin 13 (IL-13) play...

journal_title：International journal of molecular medicine

authors： Sauter A,Stern-Straeter J,Chang RC,Hörmann K,Naim R

更新日期：2008-04-01 00:00:00

abstract：:The cellular susceptibility of cancer cells to histone deacetylase (HDAC) inhibitors is increased by the etopic expression of oncogenic Ras. However, the ability of HDAC inhibitors to regulate the apoptotic pathway in human breast cancer cells is still not completely understood. In this study, the anti-proliferative e...

journal_title：International journal of molecular medicine

authors： Park H,Im JY,Kim J,Choi WS,Kim HS

更新日期：2008-03-01 00:00:00

abstract：:CDC25A is a cell cycle-activating phosphatase that promotes transition from the G1 to S phase. We previously reported that overexpression of CDC25A in human hepatocellular carcinoma (HCC) tissue samples was associated with poor prognosis. In this study, we attempted suppression of CDC25A in HCC cells to elucidate the ...

journal_title：International journal of molecular medicine

authors： Xu X,Yamamoto H,Liu G,Ito Y,Ngan CY,Kondo M,Nagano H,Dono K,Sekimoto M,Monden M

更新日期：2008-02-01 00:00:00